Background We investigated the association between the\nR.E.N.A.L. nephrometry score (RNS) and the postoperative\nrecurrence of localized renal cell carcinoma (RCC).\nMethods We retrospectively analyzed a database comprising\n91 patients with non-small localized RCC (pT1bââ?¬â??T2b)\ntreated by radical nephrectomy at our hospital from January\n2002 to March 2010. RNS was scored based on imaging\nfindings at diagnosis. The Cox proportional hazards\nmodel was used to predict recurrence-free survival (RFS)\nand to calculate hazard ratio (HR).\nResults The median age at operation was 63 years (range,\n30ââ?¬â??85 years). Postoperative recurrence occurred in 19\npatients (21 %). Median RNS sum was 9 (range, 5ââ?¬â??11).\nHigh RNS sum (10ââ?¬â??12) was significantly associated with\nRFS (P = 0.0012). Multivariate analysis revealed that high\nRNS sum [HR, 9.05; 95 % confidence interval (CI), 2.11ââ?¬â??\n63.9; P = 0.0019] were significantly associated with RFS.\nRegarding each component of RNS, only the L component,\nwhich referred to tumor location relative to the polar line,\nwas associated with RFS (HR, 15.0; 95 % CI, 2.68ââ?¬â??396;\nP = 0.0006).\nConclusions RNS was associated with RFS in cases of\nnon-small localized RCC (pT1bââ?¬â??2b), thus supporting its\nutility as a prognostic factor.
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